The 4th Annual Knoxville Brewfest will be held outdoors near the historic Southern Railway Terminal on Depot Avenue and along the Gay Street Viaduct. The event features breweries, beer and enthusiasts for an afternoon and evening of sampling fresh beers of all colors, styles and favors. All net proceeds benefit Cure Duchenne, a national nonprofit that raises awareness and funds to find a cure for Duchenne muscular dystrophy.